id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_1100
|
split_0_train_1100
|
[
{
"id": "split_0_train_1100_passage",
"type": "progene_text",
"text": [
"An increase in the expression of p27 / kipl , an inhibitor of CDK4 , was observed in cells that were treated with both IFN and TM ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_1587_entity",
"type": "progene_text",
"text": [
"p27 / kipl"
],
"offsets": [
[
33,
43
]
],
"normalized": []
},
{
"id": "split_0_train_1588_entity",
"type": "progene_text",
"text": [
"CDK4"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_1589_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
119,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1101
|
split_0_train_1101
|
[
{
"id": "split_0_train_1101_passage",
"type": "progene_text",
"text": [
"These studies suggest that insufficient formation of the active cyclin / CDK complex could possibly be deferring the cells from normal cycling and may be responsible for the ability of TM to enhance cell growth inhibition induced by IFN ."
],
"offsets": [
[
0,
238
]
]
}
] |
[
{
"id": "split_0_train_1590_entity",
"type": "progene_text",
"text": [
"cyclin"
],
"offsets": [
[
64,
70
]
],
"normalized": []
},
{
"id": "split_0_train_1591_entity",
"type": "progene_text",
"text": [
"CDK"
],
"offsets": [
[
73,
76
]
],
"normalized": []
},
{
"id": "split_0_train_1592_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
233,
236
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1102
|
split_0_train_1102
|
[
{
"id": "split_0_train_1102_passage",
"type": "progene_text",
"text": [
"Identification of murine B-cell and T-cell epitopes of Escherichia coli outer membrane protein F with synthetic polypeptides ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_1593_entity",
"type": "progene_text",
"text": [
"outer membrane protein F"
],
"offsets": [
[
72,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1103
|
split_0_train_1103
|
[
{
"id": "split_0_train_1103_passage",
"type": "progene_text",
"text": [
"The major pore - forming outer membrane proteins ( Omps ) of gram - negative bacteria demonstrate numerous immunomodulating properties and are involved in the virulence of pathogenic strains ."
],
"offsets": [
[
0,
192
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1104
|
split_0_train_1104
|
[
{
"id": "split_0_train_1104_passage",
"type": "progene_text",
"text": [
"Because Escherichia coli OmpF is the best - characterized porin in terms of structural and functional characteristics , in vitro B-cell and T-cell responses to this porin in six different strains of mice were analyzed ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_1594_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_1595_entity",
"type": "progene_text",
"text": [
"porin"
],
"offsets": [
[
165,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1105
|
split_0_train_1105
|
[
{
"id": "split_0_train_1105_passage",
"type": "progene_text",
"text": [
"Mice were immunized with purified OmpF trimers or overlapping synthetic polypeptides ( 20-mers ) spanning the entire 340 - amino - acid sequence of the OmpF monomer ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_1596_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_1597_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
152,
156
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1106
|
split_0_train_1106
|
[
{
"id": "split_0_train_1106_passage",
"type": "progene_text",
"text": [
"T-cell proliferative responses and immunoglobulin G antibody responses to native OmpF and the peptide analogues were determined ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_1598_entity",
"type": "progene_text",
"text": [
"immunoglobulin G"
],
"offsets": [
[
35,
51
]
],
"normalized": []
},
{
"id": "split_0_train_1599_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1107
|
split_0_train_1107
|
[
{
"id": "split_0_train_1107_passage",
"type": "progene_text",
"text": [
"For each strain , patterns of T-cell proliferation were similar regardless of whether native OmpF or synthetic peptides were inoculated , although all strains recognized one or more cryptic determinants ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_1600_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1108
|
split_0_train_1108
|
[
{
"id": "split_0_train_1108_passage",
"type": "progene_text",
"text": [
"Mice exhibited several haplotype - specific responses , but genetically permissive epitopes were also identified ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1109
|
split_0_train_1109
|
[
{
"id": "split_0_train_1109_passage",
"type": "progene_text",
"text": [
"Four peptides ( 75 - 94 , 265 - 284 , 295 - 314 , and 305 - 324 ) elicited strong T-cell proliferative responses from all strains of mice when mice were presensitized with native OmpF or a homologous peptide ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_1601_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
179,
183
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1110
|
split_0_train_1110
|
[
{
"id": "split_0_train_1110_passage",
"type": "progene_text",
"text": [
"In general , 10 or fewer peptides were recognized by sera from mice immunized with native OmpF or synthetic peptides , and most sera from peptide - immunized mice reacted poorly with the native protein ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_1602_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
90,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1111
|
split_0_train_1111
|
[
{
"id": "split_0_train_1111_passage",
"type": "progene_text",
"text": [
"Four peptides spanning amino acids 45 to 64 , 95 to 114 , 115 to 134 , and 275 to 294 were recognized by sera from all strains immunized with native OmpF but not by sera from peptide - immunized mice ."
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "split_0_train_1603_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
149,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1112
|
split_0_train_1112
|
[
{
"id": "split_0_train_1112_passage",
"type": "progene_text",
"text": [
"Peptides 245 - 264 and 305 - 324 were universally recognized by sera from peptide - immunized mice , but these sera reacted weakly or were negative when tested against the native protein ."
],
"offsets": [
[
0,
188
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1113
|
split_0_train_1113
|
[
{
"id": "split_0_train_1113_passage",
"type": "progene_text",
"text": [
"Based on the pattern of cytokine secretion by proliferating T cells , immunization with native OmpF polarizes T helper cells toward development of a TH1 response ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_1604_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
24,
32
]
],
"normalized": []
},
{
"id": "split_0_train_1605_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
95,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1114
|
split_0_train_1114
|
[
{
"id": "split_0_train_1114_passage",
"type": "progene_text",
"text": [
"T-cell and B-cell responses have been investigated based on the assumption that differences in epitope specificity could influence protective or pathologic host reactions ."
],
"offsets": [
[
0,
172
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1115
|
split_0_train_1115
|
[
{
"id": "split_0_train_1115_passage",
"type": "progene_text",
"text": [
"Because of the high level of structural homology of OmpF to porins isolated from other enteric pathogens , the identification of T - and B - cell - stimulatory determinants of E. coli OmpF may have broader application ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_1606_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_1607_entity",
"type": "progene_text",
"text": [
"OmpF"
],
"offsets": [
[
184,
188
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1116
|
split_0_train_1116
|
[
{
"id": "split_0_train_1116_passage",
"type": "progene_text",
"text": [
"Aquaporin adipose , a putative glycerol channel in adipocytes ."
],
"offsets": [
[
0,
63
]
]
}
] |
[
{
"id": "split_0_train_1608_entity",
"type": "progene_text",
"text": [
"Aquaporin adipose"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "split_0_train_1609_entity",
"type": "progene_text",
"text": [
"glycerol channel"
],
"offsets": [
[
31,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1117
|
split_0_train_1117
|
[
{
"id": "split_0_train_1117_passage",
"type": "progene_text",
"text": [
"Adipose tissue is a major site of glycerol production in response to energy balance ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1118
|
split_0_train_1118
|
[
{
"id": "split_0_train_1118_passage",
"type": "progene_text",
"text": [
"However , molecular basis of glycerol release from adipocytes has not yet been elucidated ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1119
|
split_0_train_1119
|
[
{
"id": "split_0_train_1119_passage",
"type": "progene_text",
"text": [
"We recently cloned a novel member of the aquaporin family , aquaporin adipose ( AQPap ) , which has glycerol permeability ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_1610_entity",
"type": "progene_text",
"text": [
"aquaporin family"
],
"offsets": [
[
41,
57
]
],
"normalized": []
},
{
"id": "split_0_train_1611_entity",
"type": "progene_text",
"text": [
"aquaporin adipose"
],
"offsets": [
[
60,
77
]
],
"normalized": []
},
{
"id": "split_0_train_1612_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1120
|
split_0_train_1120
|
[
{
"id": "split_0_train_1120_passage",
"type": "progene_text",
"text": [
"The current study was designed to examine the hypothesis that AQPap serves as a glycerol channel in adipocytes ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_1613_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_1614_entity",
"type": "progene_text",
"text": [
"glycerol channel"
],
"offsets": [
[
80,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1121
|
split_0_train_1121
|
[
{
"id": "split_0_train_1121_passage",
"type": "progene_text",
"text": [
"Adipose tissue expressed AQPap mRNA in high abundance , but not the mRNAs for the other aquaglyceroporins , AQP3 and AQP9 , indicating that AQPap is the only known aquaglyceroporin expressed in adipose tissue ."
],
"offsets": [
[
0,
210
]
]
}
] |
[
{
"id": "split_0_train_1615_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_1616_entity",
"type": "progene_text",
"text": [
"aquaglyceroporins"
],
"offsets": [
[
88,
105
]
],
"normalized": []
},
{
"id": "split_0_train_1617_entity",
"type": "progene_text",
"text": [
"AQP3"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_1618_entity",
"type": "progene_text",
"text": [
"AQP9"
],
"offsets": [
[
117,
121
]
],
"normalized": []
},
{
"id": "split_0_train_1619_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
140,
145
]
],
"normalized": []
},
{
"id": "split_0_train_1620_entity",
"type": "progene_text",
"text": [
"aquaglyceroporin"
],
"offsets": [
[
164,
180
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1122
|
split_0_train_1122
|
[
{
"id": "split_0_train_1122_passage",
"type": "progene_text",
"text": [
"Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion , which inhibits the function of AQPs , supporting AQPap functions as a glycerol channel in adipocytes ."
],
"offsets": [
[
0,
241
]
]
}
] |
[
{
"id": "split_0_train_1621_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
89,
94
]
],
"normalized": []
},
{
"id": "split_0_train_1622_entity",
"type": "progene_text",
"text": [
"AQPs"
],
"offsets": [
[
170,
174
]
],
"normalized": []
},
{
"id": "split_0_train_1623_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
188,
193
]
],
"normalized": []
},
{
"id": "split_0_train_1624_entity",
"type": "progene_text",
"text": [
"glycerol channel"
],
"offsets": [
[
209,
225
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1123
|
split_0_train_1123
|
[
{
"id": "split_0_train_1123_passage",
"type": "progene_text",
"text": [
"Fasting increased and refeeding suppressed adipose AQPap mRNA levels in accordance with plasma glycerol levels and oppositely to plasma insulin levels in mice ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_1625_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
51,
56
]
],
"normalized": []
},
{
"id": "split_0_train_1626_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
136,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1124
|
split_0_train_1124
|
[
{
"id": "split_0_train_1124_passage",
"type": "progene_text",
"text": [
"Insulin dose - dependently suppressed AQPap mRNA expression in 3T3-L1 cells ."
],
"offsets": [
[
0,
77
]
]
}
] |
[
{
"id": "split_0_train_1627_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_1628_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1125
|
split_0_train_1125
|
[
{
"id": "split_0_train_1125_passage",
"type": "progene_text",
"text": [
"AQPap mRNA levels and adipose glycerol concentrations measured by the microdialysis technique were increased in obese mice with insulin resistance ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "split_0_train_1629_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_1630_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
128,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1126
|
split_0_train_1126
|
[
{
"id": "split_0_train_1126_passage",
"type": "progene_text",
"text": [
"Accordingly , negative regulation of AQPap expression by insulin was impaired in the insulin - resistant state ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_1631_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_1632_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
57,
64
]
],
"normalized": []
},
{
"id": "split_0_train_1633_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
85,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1127
|
split_0_train_1127
|
[
{
"id": "split_0_train_1127_passage",
"type": "progene_text",
"text": [
"Exposure of epinephrine translocated AQPap protein from perinuclear cytoplasm to the plasma membrane in 3T3-L1 adipocytes ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_1634_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
37,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1128
|
split_0_train_1128
|
[
{
"id": "split_0_train_1128_passage",
"type": "progene_text",
"text": [
"These results strongly suggest that AQPap plays an important role in glycerol release from adipocytes ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_1635_entity",
"type": "progene_text",
"text": [
"AQPap"
],
"offsets": [
[
36,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1129
|
split_0_train_1129
|
[
{
"id": "split_0_train_1129_passage",
"type": "progene_text",
"text": [
"The Pseudomonas syringae Hrp pathogenicity island has a tripartite mosaic structure composed of a cluster of type III secretion genes bounded by exchangeable effector and conserved effector loci that contribute to parasitic fitness and pathogenicity in plants ."
],
"offsets": [
[
0,
261
]
]
}
] |
[
{
"id": "split_0_train_1636_entity",
"type": "progene_text",
"text": [
"Hrp"
],
"offsets": [
[
25,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1130
|
split_0_train_1130
|
[
{
"id": "split_0_train_1130_passage",
"type": "progene_text",
"text": [
"The plant pathogenic bacterium Pseudomonas syringae is divided into pathovars differing in host specificity , with P. syringae pv. syringae ( Psy ) and P. syringae pv. tomato ( Pto ) representing particularly divergent pathovars ."
],
"offsets": [
[
0,
230
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1131
|
split_0_train_1131
|
[
{
"id": "split_0_train_1131_passage",
"type": "progene_text",
"text": [
"P. syringae hrp / hrc genes encode a type III protein secretion system that appears to translocate Avr and Hop effector proteins into plant cells ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_1637_entity",
"type": "progene_text",
"text": [
"hrp"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_1638_entity",
"type": "progene_text",
"text": [
"hrc"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_1639_entity",
"type": "progene_text",
"text": [
"Avr"
],
"offsets": [
[
99,
102
]
],
"normalized": []
},
{
"id": "split_0_train_1640_entity",
"type": "progene_text",
"text": [
"Hop"
],
"offsets": [
[
107,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1132
|
split_0_train_1132
|
[
{
"id": "split_0_train_1132_passage",
"type": "progene_text",
"text": [
"DNA sequence analysis of the hrp / hrc regions in Psy 61 , Psy B728a , and Pto DC3000 has revealed a Hrp pathogenicity island ( Pai ) with a tripartite mosaic structure ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_1641_entity",
"type": "progene_text",
"text": [
"hrp"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_1642_entity",
"type": "progene_text",
"text": [
"hrc"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "split_0_train_1643_entity",
"type": "progene_text",
"text": [
"Hrp"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1133
|
split_0_train_1133
|
[
{
"id": "split_0_train_1133_passage",
"type": "progene_text",
"text": [
"The hrp / hrc gene cluster is conserved in all three strains and is flanked by a unique exchangeable effector locus ( EEL ) and a conserved effector locus ( CEL ) ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_1644_entity",
"type": "progene_text",
"text": [
"hrp"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_1645_entity",
"type": "progene_text",
"text": [
"hrc"
],
"offsets": [
[
10,
13
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1134
|
split_0_train_1134
|
[
{
"id": "split_0_train_1134_passage",
"type": "progene_text",
"text": [
"The EELs begin 3 nt downstream of the stop codon of hrpK and end , after 2.5 - 7.3 kb of dissimilar intervening DNA with tRNA ( Leu ) - queA - tgt sequences that are also found in Pseudomonas aeruginosa but without linkage to any Hrp Pai sequences ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_1646_entity",
"type": "progene_text",
"text": [
"hrpK"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_1647_entity",
"type": "progene_text",
"text": [
"queA"
],
"offsets": [
[
136,
140
]
],
"normalized": []
},
{
"id": "split_0_train_1648_entity",
"type": "progene_text",
"text": [
"tgt"
],
"offsets": [
[
143,
146
]
],
"normalized": []
},
{
"id": "split_0_train_1649_entity",
"type": "progene_text",
"text": [
"Hrp"
],
"offsets": [
[
230,
233
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1135
|
split_0_train_1135
|
[
{
"id": "split_0_train_1135_passage",
"type": "progene_text",
"text": [
"The EELs encode diverse putative effectors , including HopPsyA ( HrmA ) in Psy 61 and proteins similar to AvrPphE and the AvrB / AvrC / AvrPphC and AvrBsT / AvrRxv / YopJ protein families in Psy B728a ."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "split_0_train_1650_entity",
"type": "progene_text",
"text": [
"HopPsyA"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "split_0_train_1651_entity",
"type": "progene_text",
"text": [
"HrmA"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_1652_entity",
"type": "progene_text",
"text": [
"AvrPphE"
],
"offsets": [
[
106,
113
]
],
"normalized": []
},
{
"id": "split_0_train_1653_entity",
"type": "progene_text",
"text": [
"AvrB"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_1654_entity",
"type": "progene_text",
"text": [
"AvrC"
],
"offsets": [
[
129,
133
]
],
"normalized": []
},
{
"id": "split_0_train_1655_entity",
"type": "progene_text",
"text": [
"AvrPphC"
],
"offsets": [
[
136,
143
]
],
"normalized": []
},
{
"id": "split_0_train_1656_entity",
"type": "progene_text",
"text": [
"AvrBsT"
],
"offsets": [
[
148,
154
]
],
"normalized": []
},
{
"id": "split_0_train_1657_entity",
"type": "progene_text",
"text": [
"AvrRxv"
],
"offsets": [
[
157,
163
]
],
"normalized": []
},
{
"id": "split_0_train_1658_entity",
"type": "progene_text",
"text": [
"YopJ protein families"
],
"offsets": [
[
166,
187
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1136
|
split_0_train_1136
|
[
{
"id": "split_0_train_1136_passage",
"type": "progene_text",
"text": [
"The EELs also contain mobile genetic element sequences and have a G + C content significantly lower than the rest of the Hrp Pai or the P. syringae genome ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_1659_entity",
"type": "progene_text",
"text": [
"Hrp"
],
"offsets": [
[
121,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1137
|
split_0_train_1137
|
[
{
"id": "split_0_train_1137_passage",
"type": "progene_text",
"text": [
"The CEL carries at least seven ORFs that are conserved between Psy B728a and Pto DC3000 ."
],
"offsets": [
[
0,
89
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1138
|
split_0_train_1138
|
[
{
"id": "split_0_train_1138_passage",
"type": "progene_text",
"text": [
"Deletion of the Pto DC3000 EEL slightly reduces bacterial growth in tomato , whereas deletion of a large portion of the CEL strongly reduces growth and abolishes pathogenicity in tomato ."
],
"offsets": [
[
0,
187
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1139
|
split_0_train_1139
|
[
{
"id": "split_0_train_1139_passage",
"type": "progene_text",
"text": [
"Identification of a novel four - domain member of the proteinase inhibitor II family from the stigmas of Nicotiana alata ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_1660_entity",
"type": "progene_text",
"text": [
"proteinase inhibitor II family"
],
"offsets": [
[
54,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1140
|
split_0_train_1140
|
[
{
"id": "split_0_train_1140_passage",
"type": "progene_text",
"text": [
"Proteinase inhibitors ( PIs ) of the potato type II family have been identified in a number of solanaceous species ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_1661_entity",
"type": "progene_text",
"text": [
"Proteinase inhibitors ( PIs ) of the potato type II family"
],
"offsets": [
[
0,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1141
|
split_0_train_1141
|
[
{
"id": "split_0_train_1141_passage",
"type": "progene_text",
"text": [
"Most family members have two PI domains which are specific for either chymotrypsin or trypsin ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_1662_entity",
"type": "progene_text",
"text": [
"chymotrypsin"
],
"offsets": [
[
70,
82
]
],
"normalized": []
},
{
"id": "split_0_train_1663_entity",
"type": "progene_text",
"text": [
"trypsin"
],
"offsets": [
[
86,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1142
|
split_0_train_1142
|
[
{
"id": "split_0_train_1142_passage",
"type": "progene_text",
"text": [
"More recently family members have been described with three or six repeated PI domains ."
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1143
|
split_0_train_1143
|
[
{
"id": "split_0_train_1143_passage",
"type": "progene_text",
"text": [
"Here we describe a novel four - domain family member produced in the stigmas and leaves of the ornamental tobacco , Nicotiana alata , which has high sequence identity with a six - domain member from the same species ."
],
"offsets": [
[
0,
217
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1144
|
split_0_train_1144
|
[
{
"id": "split_0_train_1144_passage",
"type": "progene_text",
"text": [
"Both proteins are produced as precursors that enter the secretory pathway and are subsequently processed into a series of 6 kDa Pis ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1145
|
split_0_train_1145
|
[
{
"id": "split_0_train_1145_passage",
"type": "progene_text",
"text": [
"The four - and six - domain precursor proteins were isolated from immature stigmas and characterised by mass spectrometry which revealed that both proteins had been trimmed at the N - terminus , at a position corresponding to the predicted signal peptide cleavage site ."
],
"offsets": [
[
0,
270
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1146
|
split_0_train_1146
|
[
{
"id": "split_0_train_1146_passage",
"type": "progene_text",
"text": [
"Furthermore , no post - translational modifications were apparent ."
],
"offsets": [
[
0,
67
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1147
|
split_0_train_1147
|
[
{
"id": "split_0_train_1147_passage",
"type": "progene_text",
"text": [
"Liposome - mediated transfer of IL-1 receptor antagonist gene to dispersed islet cells does not prevent recurrence of disease in syngeneically transplanted NOD mice ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_1664_entity",
"type": "progene_text",
"text": [
"IL-1 receptor antagonist"
],
"offsets": [
[
32,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1148
|
split_0_train_1148
|
[
{
"id": "split_0_train_1148_passage",
"type": "progene_text",
"text": [
"IL-1beta is cytotoxic to pancreatic beta-cells in vitro but its role in the vicinity of beta-cells in vivo is unknown ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_1665_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1149
|
split_0_train_1149
|
[
{
"id": "split_0_train_1149_passage",
"type": "progene_text",
"text": [
"We explored whether liposome - mediated transfer of the interleukin 1 receptor antagonist ( IL-1ra ) gene to islet cells might prevent recurrence of disease in syngeneically transplanted non - obese diabetic ( NOD ) mice ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_1666_entity",
"type": "progene_text",
"text": [
"interleukin 1 receptor antagonist"
],
"offsets": [
[
56,
89
]
],
"normalized": []
},
{
"id": "split_0_train_1667_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
92,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1150
|
split_0_train_1150
|
[
{
"id": "split_0_train_1150_passage",
"type": "progene_text",
"text": [
"NOD mouse islet cells were transfected using liposome - mediated gene transfer with a human IL-1ra cDNA construct and transplanted two days later to prediabetic NOD mice ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_1668_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
92,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1151
|
split_0_train_1151
|
[
{
"id": "split_0_train_1151_passage",
"type": "progene_text",
"text": [
"Graft infiltration and destruction were monitored three , five and eight days posttransplantation by histology and determination of insulin and cytokine content ."
],
"offsets": [
[
0,
162
]
]
}
] |
[
{
"id": "split_0_train_1669_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
132,
139
]
],
"normalized": []
},
{
"id": "split_0_train_1670_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
144,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1152
|
split_0_train_1152
|
[
{
"id": "split_0_train_1152_passage",
"type": "progene_text",
"text": [
"IL-1ra gene transfer resulted in transient expression of IL-1ra protein in islet cells in vitro as assessed by ELISA and of IL-1ra mRNA in transplanted islets as revealed by RT - PCR ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
"id": "split_0_train_1671_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_1672_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
57,
63
]
],
"normalized": []
},
{
"id": "split_0_train_1673_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
124,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1153
|
split_0_train_1153
|
[
{
"id": "split_0_train_1153_passage",
"type": "progene_text",
"text": [
"However , both control and IL-1ra transfected NOD grafts exhibited massive infiltration and loss of insulin - positive cells , paralleled by a decreased insulin content ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_1674_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
27,
33
]
],
"normalized": []
},
{
"id": "split_0_train_1675_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
100,
107
]
],
"normalized": []
},
{
"id": "split_0_train_1676_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
153,
160
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1154
|
split_0_train_1154
|
[
{
"id": "split_0_train_1154_passage",
"type": "progene_text",
"text": [
"Increased IL-1ra expression did not clearly affect other cytokine profiles ( IL-1beta , IFN-gamma , IL-2 ) , except for an increase of IL-10 on day eight ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_1677_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
10,
16
]
],
"normalized": []
},
{
"id": "split_0_train_1678_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
57,
65
]
],
"normalized": []
},
{
"id": "split_0_train_1679_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
77,
85
]
],
"normalized": []
},
{
"id": "split_0_train_1680_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
88,
97
]
],
"normalized": []
},
{
"id": "split_0_train_1681_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
100,
104
]
],
"normalized": []
},
{
"id": "split_0_train_1682_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
135,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1155
|
split_0_train_1155
|
[
{
"id": "split_0_train_1155_passage",
"type": "progene_text",
"text": [
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split_0_train_1156
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split_0_train_1156
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"Increased nuclear factor kappa B activation in critically ill patients who die ."
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10,
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[] |
[] |
split_0_train_1157
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split_0_train_1157
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"text": [
"OBJECTIVES :"
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0,
12
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[] |
[] |
[] |
split_0_train_1158
|
split_0_train_1158
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"To determine nuclear factor kappa B ( NF-kappa B ) activation in mononuclear and neutrophils from critically ill patients and to compare NF-kappa B activation with circulating concentrations of interleukin ( IL ) - 6 , IL-8 , and soluble intercellular adhesion molecule ( sICAM ) - 1 ."
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238,
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[] |
[] |
split_0_train_1159
|
split_0_train_1159
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"DESIGN :"
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0,
8
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[] |
[] |
[] |
split_0_train_1160
|
split_0_train_1160
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"text": [
"Observational study ."
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0,
21
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[] |
[] |
[] |
[] |
split_0_train_1161
|
split_0_train_1161
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"SETTING :"
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0,
9
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[] |
[] |
[] |
[] |
split_0_train_1162
|
split_0_train_1162
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"text": [
"University Teaching Hospital , eight - bed intensive care unit in northeast Scotland ."
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0,
86
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[] |
[] |
[] |
split_0_train_1163
|
split_0_train_1163
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"id": "split_0_train_1163_passage",
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"text": [
"PATIENTS :"
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0,
10
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}
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[] |
[] |
[] |
[] |
split_0_train_1164
|
split_0_train_1164
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[
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"id": "split_0_train_1164_passage",
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"text": [
"Ten patients admitted to the intensive care unit who fulfilled the criteria for systemic inflammatory response syndrome were studied at 0 , 24 , 48 , and 72 hrs ."
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0,
162
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1165
|
split_0_train_1165
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[
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"id": "split_0_train_1165_passage",
"type": "progene_text",
"text": [
"Six healthy volunteers were also studied ."
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"offsets": [
[
0,
42
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1166
|
split_0_train_1166
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[
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"id": "split_0_train_1166_passage",
"type": "progene_text",
"text": [
"INTERVENTIONS :"
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"offsets": [
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0,
15
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}
] |
[] |
[] |
[] |
[] |
split_0_train_1167
|
split_0_train_1167
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[
{
"id": "split_0_train_1167_passage",
"type": "progene_text",
"text": [
"None ."
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0,
6
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1168
|
split_0_train_1168
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"text": [
"MEASUREMENTS AND MAIN RESULTS :"
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0,
31
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}
] |
[] |
[] |
[] |
[] |
split_0_train_1169
|
split_0_train_1169
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[
{
"id": "split_0_train_1169_passage",
"type": "progene_text",
"text": [
"NF-kappa B activation was significantly higher in patients compared to healthy volunteers in both neutrophils ( p = .001 ) and mononuclear leukocytes ( p = .013 ) ."
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0,
164
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}
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"text": [
"NF-kappa B"
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0,
10
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] |
[] |
[] |
[] |
split_0_train_1170
|
split_0_train_1170
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[
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"id": "split_0_train_1170_passage",
"type": "progene_text",
"text": [
"In the six patients who survived to 96 hrs , the level of NF-kappa B activation in mononuclear cells remained constant ( p = .9 ) ."
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0,
131
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]
}
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"text": [
"NF-kappa B"
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58,
68
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] |
[] |
[] |
[] |
split_0_train_1171
|
split_0_train_1171
|
[
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"id": "split_0_train_1171_passage",
"type": "progene_text",
"text": [
"However , in the four patients who died before 96 hrs , mononuclear cell NF-kappa B activation increased markedly and was significantly higher before death than in those who survived to 96 hrs ( p = .0105 ) ."
],
"offsets": [
[
0,
208
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]
}
] |
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"text": [
"NF-kappa B"
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[
73,
83
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}
] |
[] |
[] |
[] |
split_0_train_1172
|
split_0_train_1172
|
[
{
"id": "split_0_train_1172_passage",
"type": "progene_text",
"text": [
"NF-kappa B activation in neutrophils similarly remained constant in patients who survived to 96 hrs ( p = .4 ) but did not show the same increase before death ."
],
"offsets": [
[
0,
160
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]
}
] |
[
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"id": "split_0_train_1696_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
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"offsets": [
[
0,
10
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}
] |
[] |
[] |
[] |
split_0_train_1173
|
split_0_train_1173
|
[
{
"id": "split_0_train_1173_passage",
"type": "progene_text",
"text": [
"Circulating concentrations of IL-6 , IL-8 , and sICAM-1 were elevated but were unrelated to leukocyte NF-kappa B activation ."
],
"offsets": [
[
0,
125
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]
}
] |
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30,
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37,
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"type": "progene_text",
"text": [
"NF-kappa B"
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"offsets": [
[
102,
112
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1174
|
split_0_train_1174
|
[
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"id": "split_0_train_1174_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1175
|
split_0_train_1175
|
[
{
"id": "split_0_train_1175_passage",
"type": "progene_text",
"text": [
"We found NF-kappa B activation in mononuclear and neutrophils in patients with systemic inflammatory response syndrome , which increased markedly before death in mononuclear leukocytes and was not related to plasma IL-6 , IL-8 , and sICAM-1 concentrations ."
],
"offsets": [
[
0,
257
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]
}
] |
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9,
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215,
219
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222,
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"id": "split_0_train_1704_entity",
"type": "progene_text",
"text": [
"sICAM-1"
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"offsets": [
[
233,
240
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1176
|
split_0_train_1176
|
[
{
"id": "split_0_train_1176_passage",
"type": "progene_text",
"text": [
"These data support the need for further study of the role of NF-kappa B activation in mortality from systemic inflammatory response syndrome and sepsis ."
],
"offsets": [
[
0,
153
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]
}
] |
[
{
"id": "split_0_train_1705_entity",
"type": "progene_text",
"text": [
"NF-kappa B"
],
"offsets": [
[
61,
71
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1177
|
split_0_train_1177
|
[
{
"id": "split_0_train_1177_passage",
"type": "progene_text",
"text": [
"Identification and localization of the carboxysome peptide Csos3 and its corresponding gene in Thiobacillus neapolitanus ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_1706_entity",
"type": "progene_text",
"text": [
"Csos3"
],
"offsets": [
[
59,
64
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1178
|
split_0_train_1178
|
[
{
"id": "split_0_train_1178_passage",
"type": "progene_text",
"text": [
"Four genes encoding carboxysome shell peptides ( csoS1A , csoS1B , csoS1C , csoS2 ) , the genes encoding the large and small subunits of RuBisCO ( cbbL , cbbS ) , and three unidentified ORFs constitute an operon in Thiobacillus neapolitanus ."
],
"offsets": [
[
0,
242
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]
}
] |
[
{
"id": "split_0_train_1707_entity",
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20,
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"csoS1A"
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49,
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"csoS1B"
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58,
64
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{
"id": "split_0_train_1710_entity",
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"text": [
"csoS1C"
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67,
73
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{
"id": "split_0_train_1711_entity",
"type": "progene_text",
"text": [
"csoS2"
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76,
81
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{
"id": "split_0_train_1712_entity",
"type": "progene_text",
"text": [
"RuBisCO"
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137,
144
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},
{
"id": "split_0_train_1713_entity",
"type": "progene_text",
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"cbbL"
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147,
151
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},
{
"id": "split_0_train_1714_entity",
"type": "progene_text",
"text": [
"cbbS"
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"offsets": [
[
154,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1179
|
split_0_train_1179
|
[
{
"id": "split_0_train_1179_passage",
"type": "progene_text",
"text": [
"An unidentified ORF 1.54 kb in size is predicted from sequence analysis to encode a protein with a molecular mass of approximately 57 kDa ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1180
|
split_0_train_1180
|
[
{
"id": "split_0_train_1180_passage",
"type": "progene_text",
"text": [
"When this ORF was expressed in Escherichia coli under the control of its endogenous ribosome - binding site , no peptide product was observed ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1181
|
split_0_train_1181
|
[
{
"id": "split_0_train_1181_passage",
"type": "progene_text",
"text": [
"In order to correlate this ORF with a carboxysome peptide , the ORF was overexpressed in E. coli by cloning it into pProExHTb , a prokaryotic expression vector containing an E. coli ribosome binding site ."
],
"offsets": [
[
0,
205
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1182
|
split_0_train_1182
|
[
{
"id": "split_0_train_1182_passage",
"type": "progene_text",
"text": [
"When antibodies raised against the recombinant protein were used to probe an immunoblot containing carboxysome peptides , a 60 - kDa peptide was recognized ."
],
"offsets": [
[
0,
157
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1183
|
split_0_train_1183
|
[
{
"id": "split_0_train_1183_passage",
"type": "progene_text",
"text": [
"The peptide was subsequently named CsoS3 ."
],
"offsets": [
[
0,
42
]
]
}
] |
[
{
"id": "split_0_train_1715_entity",
"type": "progene_text",
"text": [
"CsoS3"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1184
|
split_0_train_1184
|
[
{
"id": "split_0_train_1184_passage",
"type": "progene_text",
"text": [
"CsoS3 is a minor component of the carboxysome ; a peptide of this size is commonly not observed or is very faint on Coomassie blue - stained SDS - polyacrylamide gels of purified carboxysomes ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_1716_entity",
"type": "progene_text",
"text": [
"CsoS3"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1185
|
split_0_train_1185
|
[
{
"id": "split_0_train_1185_passage",
"type": "progene_text",
"text": [
"Immunogold labeling established CsoS3 to be a component of the carboxysome shell ."
],
"offsets": [
[
0,
82
]
]
}
] |
[
{
"id": "split_0_train_1717_entity",
"type": "progene_text",
"text": [
"CsoS3"
],
"offsets": [
[
32,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1186
|
split_0_train_1186
|
[
{
"id": "split_0_train_1186_passage",
"type": "progene_text",
"text": [
"The oestrogenic effects of gestodene , a potent contraceptive progestin , are mediated by its A - ring reduced metabolites ."
],
"offsets": [
[
0,
124
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1187
|
split_0_train_1187
|
[
{
"id": "split_0_train_1187_passage",
"type": "progene_text",
"text": [
"Gestodene ( 17 alpha-ethynyl-13 beta-ethyl-17 beta-hydroxy-4 , 15-gonadien-3-one ) is the most potent synthetic progestin currently available and it is widely used as a fertility regulating agent in a number of contraceptive formulations because of its high effectiveness , safety and acceptability ."
],
"offsets": [
[
0,
300
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1188
|
split_0_train_1188
|
[
{
"id": "split_0_train_1188_passage",
"type": "progene_text",
"text": [
"The observation that contraceptive synthetic progestins exert hormone - like effects other than their progestational activities , prompted us to investigate whether gestodene ( GSD ) administration may induce oestrogenic effects , even though the GSD molecule does not interact with intracellular oestrogen receptors ( ER ) ."
],
"offsets": [
[
0,
325
]
]
}
] |
[
{
"id": "split_0_train_1718_entity",
"type": "progene_text",
"text": [
"oestrogen receptors"
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"offsets": [
[
297,
316
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],
"normalized": []
},
{
"id": "split_0_train_1719_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
319,
321
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1189
|
split_0_train_1189
|
[
{
"id": "split_0_train_1189_passage",
"type": "progene_text",
"text": [
"To assess whether GSD may exert oestrogenic effects through some of its neutral metabolites , a series of experimental studies were undertaken using GSD and three of its A-ring reduced metabolites ."
],
"offsets": [
[
0,
198
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1190
|
split_0_train_1190
|
[
{
"id": "split_0_train_1190_passage",
"type": "progene_text",
"text": [
"Receptor binding studies by displacement analysis confirmed that indeed GSD does not bind to the ER , whereas its 3 beta,5 alpha-tetrahydro reduced derivative ( 3 beta GSD ) interacts with a relative high affinity with the ER ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_1720_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
97,
99
]
],
"normalized": []
},
{
"id": "split_0_train_1721_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
223,
225
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1191
|
split_0_train_1191
|
[
{
"id": "split_0_train_1191_passage",
"type": "progene_text",
"text": [
"The 3 alpha,5 alpha GSD isomer ( 3 alpha GSD ) also binds to the ER , though to a lesser extent ."
],
"offsets": [
[
0,
97
]
]
}
] |
[
{
"id": "split_0_train_1722_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
65,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1192
|
split_0_train_1192
|
[
{
"id": "split_0_train_1192_passage",
"type": "progene_text",
"text": [
"The ability of the A - ring reduced GSD derivatives to induce oestrogenic actions was evaluated by the use of two different molecular bioassays : (a) transactivation of a yeast system co - transfected with the human ER alpha ( hER alpha ) gene and oestrogen responsive elements fused to the beta-galactosidase reporter vector and ( b ) transactivation of the hER alpha - mediated transcription of the chloramphenicol acetyl transferase ( CAT ) reporter gene in a HeLa cells expression system ."
],
"offsets": [
[
0,
493
]
]
}
] |
[
{
"id": "split_0_train_1723_entity",
"type": "progene_text",
"text": [
"ER alpha"
],
"offsets": [
[
216,
224
]
],
"normalized": []
},
{
"id": "split_0_train_1724_entity",
"type": "progene_text",
"text": [
"hER alpha"
],
"offsets": [
[
227,
236
]
],
"normalized": []
},
{
"id": "split_0_train_1725_entity",
"type": "progene_text",
"text": [
"beta-galactosidase"
],
"offsets": [
[
291,
309
]
],
"normalized": []
},
{
"id": "split_0_train_1726_entity",
"type": "progene_text",
"text": [
"hER alpha"
],
"offsets": [
[
359,
368
]
],
"normalized": []
},
{
"id": "split_0_train_1727_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyl transferase"
],
"offsets": [
[
401,
435
]
],
"normalized": []
},
{
"id": "split_0_train_1728_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
438,
441
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1193
|
split_0_train_1193
|
[
{
"id": "split_0_train_1193_passage",
"type": "progene_text",
"text": [
"The oestrogenic potency of 3 beta GSD was also assessed by its capability to induce oestrogen - dependent progestin receptors ( PR ) in the anterior pituitary of castrated female rats ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_1729_entity",
"type": "progene_text",
"text": [
"progestin receptors"
],
"offsets": [
[
106,
125
]
],
"normalized": []
},
{
"id": "split_0_train_1730_entity",
"type": "progene_text",
"text": [
"PR"
],
"offsets": [
[
128,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1194
|
split_0_train_1194
|
[
{
"id": "split_0_train_1194_passage",
"type": "progene_text",
"text": [
"The results demonstrated that 3 beta GSD and 3 alpha GSD were able to activate , in a dose - dependent manner , the hER alpha - mediated transcription of both the beta-galactosidase and the CAT reporter genes in the yeast and HeLa cells expression systems respectively ."
],
"offsets": [
[
0,
270
]
]
}
] |
[
{
"id": "split_0_train_1731_entity",
"type": "progene_text",
"text": [
"hER alpha"
],
"offsets": [
[
116,
125
]
],
"normalized": []
},
{
"id": "split_0_train_1732_entity",
"type": "progene_text",
"text": [
"beta-galactosidase"
],
"offsets": [
[
163,
181
]
],
"normalized": []
},
{
"id": "split_0_train_1733_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
190,
193
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1195
|
split_0_train_1195
|
[
{
"id": "split_0_train_1195_passage",
"type": "progene_text",
"text": [
"In both assays the 3 beta derivative of GSD exhibited a significantly greater oestrogenic effect than its 3 alpha isomer , while unchanged GSD and 5 alpha GSD were completely ineffective ."
],
"offsets": [
[
0,
188
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1196
|
split_0_train_1196
|
[
{
"id": "split_0_train_1196_passage",
"type": "progene_text",
"text": [
"Neither 3 beta GSD nor 3 alpha GSD exhibited oestrogen synergistic actions ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1197
|
split_0_train_1197
|
[
{
"id": "split_0_train_1197_passage",
"type": "progene_text",
"text": [
"Interestingly , the pure steroidal anti - oestrogen ICI-182,780 diminished the transactivation induced by 3 beta GSD and 3 alpha GSD in the yeast expression system ."
],
"offsets": [
[
0,
165
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_1198
|
split_0_train_1198
|
[
{
"id": "split_0_train_1198_passage",
"type": "progene_text",
"text": [
"Furthermore , administration of 3 beta GSD resulted in a significant increase of oestrogen - dependent PR in the anterior pituitaries of castrated rats in comparison with vehicle - treated animals ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_1734_entity",
"type": "progene_text",
"text": [
"PR"
],
"offsets": [
[
103,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_1199
|
split_0_train_1199
|
[
{
"id": "split_0_train_1199_passage",
"type": "progene_text",
"text": [
"The characteristics of the 3 beta GSD - induced PR were identical to those induced by oestradio benzoate ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_1735_entity",
"type": "progene_text",
"text": [
"PR"
],
"offsets": [
[
48,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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